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Root Medicine

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  • #54 - Dalibor Sames: When the Researcher Finally Takes the Medicine

#54 - Dalibor Sames: When the Researcher Finally Takes the Medicine

Tuesday 23rd December 2025

Join Dr. Dalibor Sames as he shares his personal journey with ibogaine, revealing its potential to revolutionise mental health treatment.
56 minutes
Informative
Inspiring
Eye-opening
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Hopeful

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Root Medicine
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When Science Meets Experience: Dr. Dalibor Sames on Ibogaine

Episode Overview

  • Dr. Sames shares his personal experience with ibogaine after years of research.
  • Ibogaine may interact with multiple systems rather than a single receptor.
  • Potential to treat PTSD, TBI, and aid in addiction recovery.
  • Ethical discussions on developing safer ibogaine analogs.
  • Personal experiences can shape and revolutionise scientific understanding.
"Ibogaine really works in a way that it starts manipulating traffic throughout the entire Manhattan."
Curious about what happens when a scientist steps into the world of his own research? Dr. Dalibor Sames, a chemist and Columbia University researcher, takes listeners on an intriguing journey as he shares his personal encounter with ibogaine, a molecule he's studied for two decades. Host Talia Eisenberg delves into Dr. Sames' groundbreaking theories, like matrix pharmacology, which suggest that ibogaine interacts with multiple systems simultaneously rather than targeting a single receptor.
This episode isn't just about the science; it's about the profound impact ibogaine can have on mental health treatment and addiction recovery. You'll hear about the molecule's potential to repair synapses and its role in treating conditions like PTSD and TBI. Dr. Sames even describes his own experience with ibogaine as meeting a 'living teacher,' which guided him through new scientific insights.
The conversation also touches on the ethical questions surrounding the development of ibogaine analogs, aiming to reduce cardiac risks and increase accessibility. This is more than just a scientific discussion; it's a fascinating look at how personal experiences can shape scientific understanding and potentially revolutionise mental health care. Are you ready to explore the possibilities of a molecule that could redefine healing?
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