Sameer Dossani
Sameer Dossani
#77 Cholesterol Hyper Responders with Dave Feldman
#77 Cholesterol Hyper Responders with Dave Feldman
#77 Cholesterol Hyper Responders with Dave Feldman
Sunday 21st September 2025
Engineer Dave Feldman questions cholesterol myths, revealing why plaque—not LDL—might predict heart disease. Discover groundbreaking insights.
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67 minutes
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Sameer Dossani
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Get the buttons here!Challenging Cholesterol Myths: A Conversation with Dave Feldman
Episode Overview
- Plaque may be a more accurate predictor of heart disease risk than LDL cholesterol.
- Lean mass hyper-responders offer unique insights into cholesterol levels.
- Metabolic health plays a crucial role in heart disease risk.
- The scientific method involves disproving hypotheses rather than proving them.
- Genetic factors can influence lipid profiles and heart disease risk.
"Would high LDL associate with heart disease in the same way, at the same rate that we see in other populations?"
What drives someone to question mainstream beliefs about cholesterol and heart disease? In this episode, Dave Feldman returns to the podcast to challenge the lipid-heart hypothesis with intriguing data from the Keto-CTA study. Feldman, an engineer turned lipid researcher, shares his journey from personal curiosity to conducting groundbreaking studies on lean mass hyper-responders. If you've ever wondered whether 'bad cholesterol' is as harmful as we've been led to believe, Feldman's insights might surprise you.
The episode covers why LDL levels might not be the villain they're often portrayed as and how plaque, rather than cholesterol, could be the real predictor of heart disease risk. The discussion also touches on metabolic health, exercise, and genetic factors that play a role in heart disease. Feldman uses an engaging analogy involving volcanoes and hospitals to illustrate causality, making complex scientific concepts accessible.
He argues that the reasons behind high LDL levels might be more relevant than previously thought. With a mix of technical detail and relatable examples, this episode is a must-listen for anyone curious about the evolving science of cholesterol and heart disease. Could it be time to rethink what we know about heart health?