How Global Genetic Diversity Sheds Light on Tobacco and Alcohol Use
The authors found that increases in sample size and genetic diversity improved locus identification and fine-mapping resolution, and that a large majority of the associated variants showed consistent effect sizes across ancestry dimensions.
Have you ever wondered how our genes influence our habits? In this episode of 'This Week in Addiction Medicine from ASAM', host Claire Rasmussen dives into a groundbreaking study that taps into the genetic diversity of 3.4 million individuals from various global ancestries. This research isn't just about numbers; it's about uncovering how different genetic backgrounds can help pinpoint genomic loci linked to tobacco and alcohol use.
The study highlights that larger, more diverse sample sizes significantly improve the accuracy of identifying these genetic markers. However, it also points out that polygenic risk scores developed for one ancestry group often don't translate well to others, emphasizing the need for more inclusive research. But that's not all. The episode also brings expert opinions on a variety of other topics.
From innovative patient-centered models for treating hepatitis C in people who inject drugs, to the growing potential of virtual-first telehealth treatments for opioid use disorder, there's a wealth of information packed into this episode. Whether you're a healthcare professional looking to stay updated or someone dealing with substance use issues, you'll find valuable insights and practical advice here.
So, if you're curious about how genetic diversity can shape our understanding of addiction or want to explore new treatment models, this episode is a must-listen. Tune in and expand your knowledge on these crucial topics.