MDMA, anxiety, and depression with Zachary BryantMDMA, anxiety, and depression with Zachary Bryant
Addiction Audio
Dr Tsen Vei Lim and Zachary Bryant discuss the potential long-term mental health effects of MDMA use, highlighting its link to anxiety but not depression.
17:13•31 Oct 2025
MDMA's Hidden Impact on Anxiety and Depression
Episode Overview
- MDMA use in youth may increase anxiety risk by mid-30s.
- No strong link found between MDMA and later depression.
- Biological effects of MDMA impact neurotransmitters like serotonin.
- Potential self-medication among MDMA users is discussed.
- Findings could influence public health strategies and clinical practices.
“"We found little evidence of an association between MDMA and later depression, but a higher risk of anxiety disorders."”
What drives someone to seek a life without alcohol? In this episode, Dr Tsen Vei Lim chats with Zachary Bryant, a PhD candidate at the University of Sydney, about his research on the long-term mental health effects of MDMA use. Zachary's work dives into whether recreational use of MDMA in youth can lead to anxiety or depression later in life. He uses the Victorian Adolescent Health Cohort Study to explore this complex relationship.
You'll learn about MDMA's impact on neurotransmitters and why its use is so prevalent among young adults in Australia. The episode uncovers some surprising findings: while there's little evidence linking MDMA to later depression, there's a noticeable connection to increased anxiety disorders by mid-30s. Zachary discusses potential reasons for this, touching on the biological effects of MDMA and the possibility of self-medication among users.
Listeners will gain insights into how these findings could shape public health strategies and inform clinical practices. With a mix of scientific rigor and engaging conversation, this episode offers a thoughtful look at the implications of MDMA use, making it a must-listen for anyone interested in mental health and substance use research. So, are you ready to rethink what you know about MDMA and its long-term effects?

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