The Biology Behind It: Why You’re Antidepressants May Not Be Working

The Biology Behind It: Why You’re Antidepressants May Not Be Working

The Biology of Trauma™ With Dr. Aimie

Did you know that, according to research, only 50% of people experience relief from antidepressants? Why could this be? In this mini-episode, Dr. Aimie explores why antidepressants often fail to provide relief for many people, expanding on her...

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18:598 May 2025

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Why Antidepressants Might Not Be Working: Unpacking Trauma's Role

Episode Overview

  • Antidepressants may only work for 50% due to underlying trauma biology.
  • Brain inflammation can affect mood and mental health significantly.
  • Five-step trauma response could be key to understanding depression.
  • Lifestyle changes like diet and sleep can help reduce brain inflammation.
  • Addressing root causes is crucial for effective mental health treatment.
"It's like trying to fix a leaky roof with a new paint job - it looks better, but the underlying problem remains".

Why aren't your antidepressants working? Dr. Aimie tackles this pressing question with a deep dive into the biology of trauma and its impact on mental health. In this episode of 'The Biology of Trauma™ With Dr. Aimie', she uncovers the surprising truth behind why antidepressants may fail to bring relief to many. With an engaging blend of science and personal anecdotes, Dr. Aimie sheds light on the often-overlooked role of brain inflammation in mood disorders. Dr.

Aimie explores how trauma affects our biology at a cellular level, potentially leading to symptoms like brain fog and emotional flatness. She highlights the critical five-step trauma response that our bodies undergo, which could be the missing link in understanding why traditional treatments might not be hitting the mark. It's a bit like trying to fix a leaky roof with a new paint job - it looks better, but the underlying problem remains.

Lisa's question about her ongoing struggles with Lexapro sparks a broader discussion on how trauma biology might be influencing mental health challenges. Dr. Aimie emphasises the need to address brain inflammation as a root cause, pointing out that without tackling this, antidepressants might only offer a 50-50 chance of relief. This episode is packed with insights into how lifestyle factors like sleep and diet can trigger or alleviate brain inflammation. Dr.

Aimie shares practical tips for reducing inflammation, such as optimising your sleep environment and incorporating omega-3 rich foods into your diet. If you're looking for a fresh perspective on mental health treatment, this episode offers valuable advice and hope. Dr. Aimie's approach is both compassionate and enlightening, making it a must-listen for anyone seeking to understand the complex interplay between trauma and mental health.

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