Jacqueline Trumbull and Kibby McMahon
Dr. Kibby McMahon
Interview with Dr. Geoffrey Grammer: New Frontiers in Treating Depression When Meds Fail
Interview with Dr. Geoffrey Grammer: New Frontiers in Treating Depression When Meds Fail
Interview with Dr. Geoffrey Grammer: New Frontiers in Treating Depression When Meds Fail
Wednesday 19th November 2025
Explore TMS and nasal esketamine as innovative solutions for treatment-resistant depression with Dr. Geoffrey Grammer.
52 minutes
Informative
Hopeful
Inspiring
Educational
Encouraging
About this podcast
Author:
Jacqueline Trumbull and Kibby McMahon
Overview:
Categories:
Recovery from Trauma
Sobriety Toolkit
Healing Relationships
Navigating Intimate Relationships
Relationships & Community
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Episodes:
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Get the buttons here!Breaking Boundaries: New Treatments for Depression
Episode Overview
- A third of patients don't respond to traditional antidepressants.
- TMS offers targeted stimulation for underactive brain areas.
- Nasal esketamine provides relief with a unique mechanism.
- Innovative treatments can break the cycle of ineffective medication trials.
- Personalised approaches are crucial for effective mental health care.
"It's the medications that are failing the patient, not the other way around."
How do individuals turn their lives around after addiction? In this captivating episode, Dr. Geoffrey Grammer, psychiatrist and CMO of Neuronetics, joins hosts Jacqueline Trumbull and Dr. Kibby McMahon to discuss groundbreaking treatments for depression when traditional medications fall short. Dr. Grammer shares eye-opening statistics about treatment-resistant depression, revealing that a third of patients don't find relief with standard antidepressants. The conversation takes a fascinating turn as Dr.
Grammer introduces transcranial magnetic stimulation (TMS) and nasal esketamine as promising alternatives for those who haven't found success with conventional therapies. These innovative approaches offer hope to many who feel trapped in the cycle of ineffective medication trials. Listeners will be intrigued by the comparison of TMS to physical therapy for the brain, where targeted magnetic fields stimulate underactive areas to alleviate depressive symptoms.
The episode also delves into the benefits of nasal esketamine, highlighting its unique mechanism and its ability to bring relief to those with treatment-resistant depression. Through engaging anecdotes and expert insights, this episode challenges preconceived notions about mental health treatments and encourages a broader understanding of available options. As Dr.
Grammer puts it, "It's the medications that are failing the patient, not the other way around." If you're curious about cutting-edge therapies or seeking alternatives for yourself or a loved one, this episode is a must-listen. So, what does the future hold for depression treatment? Could these new therapies be the key to breaking free from the grip of persistent depression? Tune in to find out!