55. How Buprenorphine Works in Pregnancy55. How Buprenorphine Works in Pregnancy
Addiction Medicine Journal Club
Explore how buprenorphine works in pregnancy, issues in recovery houses, and rising alcohol-related deaths with Dr. John Keenan and Dr. Sonia Del Tredici.
35:23•27 Jan 2025
Understanding Buprenorphine Use During Pregnancy
Episode Overview
- Pregnant individuals need higher doses of buprenorphine for effective treatment.
- Fraudulent practices in some recovery houses can hinder patient recovery.
- Alcohol-related deaths have doubled in the past two decades.
- Splitting buprenorphine doses may help maintain therapeutic levels.
- Clinical practices should adapt to the unique needs of pregnant patients.
“Pregnant people require higher doses of buprenorphine to achieve concentrations comparable to non-pregnant people”
Ever wondered how buprenorphine works in pregnancy? This episode of Addiction Medicine Journal Club is a must-listen. Dr. John Keenan and Dr. Sonia Del Tredici break down the complex pharmacokinetics and pharmacodynamics of buprenorphine during pregnancy. They dive into the findings of a recent study published in the Journal of Addiction Medicine, which highlights the need for higher doses of buprenorphine in pregnant individuals to maintain therapeutic levels.
The hosts share their own experiences and discuss the implications of these findings for clinical practice. The episode also touches on alarming issues such as fraud in Baltimore recovery houses and the doubling of alcohol-related deaths over the past two decades. It's a mix of technical insights and real-world implications, making it both informative and engaging. If you're involved in addiction medicine or simply curious about the topic, this episode offers valuable perspectives and practical advice.
Tune in to learn more about the challenges and solutions in treating opioid use disorder during pregnancy.

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