Genetic influence in addiction with Wei DengGenetic influence in addiction with Wei Deng
Addiction Audio
Dr Wei Deng discusses her research on genetic influences in addiction, focusing on 'externalising' behaviours and polygenic risk scores with host Dr Rob Calder.
19:24•19 Sept 2025
The Genetic Threads of Addiction with Dr Wei Deng
Episode Overview
- Genetics play a significant role in the development of addiction, with a heritability component between 50% to 70%.
- 'Externalising' behaviours are key indicators of genetic predisposition to addiction.
- Polygenic risk scores help estimate an individual's genetic risk for addiction.
- Addictions may share a common genetic basis, leading to comorbid disorders.
- Adolescence is a critical period for genetic influences on externalising behaviours.
“"Is this the root cause of addiction? That requires more analysis and perhaps research into the future."”
What role does genetics play in addiction? In this engaging episode of Addiction Audio, Dr Rob Calder sits down with Dr Wei Deng, an assistant professor from McMaster University and St Joseph’s Healthcare Hamilton, to discuss the genetic factors that may influence substance use and behavioural conditions. Drawing from her research on a large UK longitudinal dataset, Dr Deng explores the concept of 'externalising'—a type of outward-directed behaviour linked to risky actions like substance use and aggression.
This episode unpacks the concept of polygenic risk scores, which estimate a person's inherited risk for addiction based on genetic variants. Dr Deng shares how these scores can serve as a 'genetic meter' to gauge an individual's susceptibility to addiction-related outcomes. The conversation also touches on the idea that many addictive behaviours may share a common genetic basis, challenging the notion that they should be viewed in isolation.
With fascinating insights into the genetic and environmental factors influencing addiction, this episode is a must-listen for anyone curious about the science behind addiction. Are you ready to rethink what you know about the roots of addiction?
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