Perinatal Pharmacokinetics and Serum Methadone/Metabolite RatiosPerinatal Pharmacokinetics and Serum Methadone/Metabolite Ratios
Addiction Medicine: Beyond the Abstract
In episode nine of Addiction Medicine: Beyond the Abstract, we are joined by Dr. John McCarthy, an associate professor of psychiatry and volunteer clinical faculty at the University of California Davis. In his recent study, Dr. McCarthy and his col...
11:38•27 Nov 2018
Guiding Methadone Dosing in Pregnancy: Dr. McCarthy's Insights
“I used the data. I had no idea when I started, Sean, what the hell methadone metabolite ratios were good for. I never heard of them. I didn't know anything about them. But I had ordered serum levels all the time on pregnant patients because I wanted to know the best measure of metabolism I could get.”
Ever thought about how methadone dosing changes during pregnancy? Dr. John McCarthy, an associate professor of psychiatry and a volunteer clinical faculty member at the University of California Davis, dives into this very topic. In this episode of 'Addiction Medicine: Beyond the Abstract', he shares his journey from community mental health to leading a methadone program, and the fascinating research that came out of it. Dr.
McCarthy and his team explored the significance of serum methadone/metabolite ratios (MMRs) in pregnant women. They discovered that these ratios can be crucial for guiding methadone dosing throughout pregnancy. You'll hear about the science behind enzyme induction and its impact on methadone metabolism, as well as the clinical outcomes and the value of serum models in addiction medicine. If you're interested in how addiction treatment adapts to the unique needs of pregnant patients, this episode is a must-listen.
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