Dr. David Sinclair's Supplement Shake-Up: What You Need to Know
Episode Overview
David Sinclair has switched from metformin to berberine for blood glucose control. NMN is still part of Sinclair's routine but with caution due to contamination risks. Resveratrol remains a staple in Sinclair's regimen for activating sirtuins. Sinclair continues to take spermidine for its longevity benefits. Creatine is not yet included in Sinclair's supplement list.
"If NMN makes you happy, I will never argue with happiness".
In this episode of The Wellness Messiah Podcast, Rimon, a seasoned metabolic researcher, dives into Dr. David Sinclair's updated supplement routine for 2025. Sinclair, a renowned figure in the longevity field, has made significant tweaks to his regimen, which might surprise his followers. Rimon dissects these changes with his characteristic flair, offering listeners a simplified guide to Sinclair's complex protocol. You'll hear about Sinclair's switch from metformin to berberine, a plant-based alternative he now favours for its blood glucose-lowering effects.
He seems to have reduced his metformin intake significantly, opting for berberine most days. This pivot is just one of many updates Sinclair has made, including his continued use of NMN, a supplement that boosts NAD levels, although with some caution due to potential contaminants. Sinclair's stance on creatine remains unchanged—he's not yet onboard with this popular anti-aging supplement. However, he's still committed to resveratrol, mixing it into his morning yogurt for its sirtuin-activating properties.
Rimon also touches on Sinclair's use of spermidine and natokinase, both critical elements in his daily routine. If you're curious about Sinclair's latest experiments and want to know how they might fit into your lifestyle, this episode is a must-listen. Rimon's engaging breakdown makes the science accessible and relatable, leaving you with plenty to ponder about your own longevity journey. What changes could you make today to enhance your health and wellbeing?