Ep131 Dr Joshua Helman

Ep131 Dr Joshua Helman

Unpause Your Life

In this episode of Unpause Your Life, I sit down with Dr. Joshua Helman, a Harvard-trained physician, board-certified in both Emergency Medicine and Lifestyle Medicine, and a leading voice in the conversation around Alzheimer’s prevention and...

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35:0814 May 2026

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Toxins, Alzheimer’s and Addiction: Dr. Josh on Healing the Brain at its Roots

Episode Overview

  • Alzheimer’s and dementia may have dozens to hundreds of root causes, with brain inflammation playing a central role.
  • Gut inflammation, toxins and infections can strongly affect the brain, contributing to brain fog, mood changes and cognitive decline.
  • Plastics, forever chemicals and other environmental toxins accumulate over decades and may be linked to conditions such as autism, obesity and early-onset Alzheimer’s.
  • Advanced detox approaches like glutathione support, therapeutic plasma exchange, ozone-based therapies and colonics are used to help lower toxic load.
  • Reducing brain inflammation and toxic burden may lessen addictive tendencies, suggesting addiction is more than just a matter of willpower.
"Just because something's expensive doesn't mean that it's actually health promoting."

What drives someone to seek a life without brain fog, chronic illness, and future dementia hanging over their head? This conversation on **Unpause Your Life** brings together addiction specialist Dr. Cali Estes and Harvard-trained physician Dr. Joshua Helman ("Dr. Josh") to talk about how everyday toxins, inflammation, and lifestyle choices may be linked to Alzheimer’s, brain disorders, and even addictive tendencies. You’ll hear Dr.

Josh explain his niche: helping people prevent and reverse Alzheimer’s and other brain issues by hunting for root causes rather than handing out labels. He shares how his own grandmother’s diagnosis, plus his background in biochemistry and emergency medicine, pushed him into this field.

As he puts it, "Just because something's expensive doesn't mean that it's actually health promoting." The conversation ranges from brain scans and early signs of cognitive decline to gut health, plastics, mould, Lyme, and so‑called "forever chemicals". Dr. Josh talks about patients in their late 40s with early Alzheimer’s and teenagers whose brains are affected by mould or toxins, stressing that inflammation and toxic load can show up as depression, anxiety, or brain fog long before obvious memory loss.

He and Dr. Cali compare traditional medicine’s quick-diagnosis, pill-based model with a slower, deeper approach that checks blood work, toxins, gut health and lifestyle. They also touch on advanced detox tools like glutathione, colonics, and therapeutic plasma exchange, and how reducing inflammation in the brain may lessen a person’s drive toward addiction.

For anyone curious about root-cause healing, worried about dementia in the family, or feeling let down by "take this and get on with it" medicine, this chat offers a different way of thinking. It might make you look twice at your cookware, your clothes, and even that plastic cup in your hand. Could changing those things be part of unpausing your life?

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